Diversity of antimicrobial peptides and their mechanisms of action. Abstract. Antimicrobial peptides encompass a wide variety of structural motifs. The majority of these peptides are cationic and amphipathic but there are also hydrophobic . There are also antimicrobial peptides which are rich in a certain specific amino acid such as Trp or His. In addition, antimicrobial peptides exist with thio- ether rings, which are lipopeptides or which have macrocyclic Cys knots. In spite of the structural diversity, a common feature of the cationic antimicrobial peptides is that they all have an amphipathic structure which allows them to bind to the membrane interface. Indeed, most antimicrobial peptides interact with membranes and may be cytotoxic as a result of disturbance of the bacterial inner or outer membranes. Alternatively, a necessary but not sufficient property of these peptides may be to be able to pass through the membrane to reach a target inside the cell. The interaction of these peptides with biological membranes is not just a function of the peptide but is also modulated by the lipid components of the membrane. It is not likely that this diverse group of peptides has a single mechanism of action, but interaction of the peptides with membranes is an important requirement for most, if not all, antimicrobial peptides. Antimicrobial peptides encompass a wide variety of structural motifs. The majority of these peptides are cationic and. N.Geetha et al /Int.J.PharmTech Res.2014,6(2),pp 521-529. 522 Previously the crude drugs/extracts prepared from plants were identified by comparison only with the. Antimicrobial Peptides. AMPs are widely distributed throughout nature and have been discovered in certain bacteria, protozoa, fungi, plants, and multicellular. Keywords. Cytotoxic peptide; Peptide- lipid interaction; Membrane permeability; Peptide conformation; Lipopolysaccharide. Introduction. Organisms from throughout the phylogenetic tree, including animals . Many of these substances are peptides. With the growing problem of pathogenic organisms which are resistant to conventional antibiotics, there is increased interest in the pharmacological application of antimicrobial peptides to treat infection. Efforts are currently underway to increase the potency and specificity of these peptides so that they are toxic to microbes and not to mammals. In order to achieve this in an efficient manner, it is important to understand the mechanism of action of these agents and the reason for their selectivity against microbes. Even limiting consideration of antimicrobial agents to peptides, there is still a large variety of structures known. This makes the task for designing improved agents more complex, but at the same time, it provides a range of opportunities for further development. The classification of antimicrobial peptides is somewhat arbitrary and there exist analogs with similar sequences but different conformational motifs which would fall into different classes, despite the similarity of their chemical structure and possibly also of their mechanism of action. Nevertheless, to simplify the problem and to illustrate the range of structures of peptides with antimicrobial activities, we have divided these peptides into groups. These groups include linear peptides which form amphipathic and hydrophobic helices, cyclic peptides and small proteins which form . We will discuss what is known about the structure and the mechanism of action of each of these classes of antimicrobial peptides individually. In general, the mechanism of action of any of these agents is not very well established. For many of these peptides, there is evidence that one of the targets for the peptide is the lipid bilayer of the membrane. Available online a t www.scholarsresearchlibrary.com Scholars Research Library J. Plant Resour., 2012, 2 (1):89-100 (http://scholarsresearchlibrary.com. Antimicrobial peptides (AMPs), also called host defense peptides (HDPs) are part of the innate immune response found among all classes of life. This is because these peptides can often increase the rate of leakage of the internal aqueous contents of liposomes. In addition, most of the antimicrobial peptides are cationic and their interaction with anionic phospholipids would provide a ready explanation for their specificity for bacterial membranes. In Gram- negative bacteria, both the outer leaflet of the plasma membrane as well as the outer membrane contain anionic molecules oriented towards the exterior of the cell. This is not the case for mammalian membranes. Hence, the cationic antimicrobial peptides will preferentially bind to the exposed negative charges of bacterial membranes, but not to the zwitterionic amphiphiles present in the extracellular monolayer of mammalian plasma membranes. This specificity for anionic membrane components is also mimicked in model liposome studies. There is uncertainty, however, about how these peptides perturb the membrane and whether this membrane perturbation is related to the antimicrobial activity of these peptides. It has recently been shown that there is not always a correlation between the ability of peptides to permeabilize membranes and their antimicrobial activity . It is possible that the membrane effects of these peptides are not directly related to their mechanism of cytotoxic action but rather simply the manner by which they enter the cell to reach an alternative target . For example, the amphipathic helical peptide, cecropin, will dissipate a transmembrane electrochemical gradient at a low peptide concentration but requires a higher concentration to affect the release of an encapsulated fluorescent probe . This peptide is cytotoxic to Gram- negative bacteria at low concentrations which dissipate ion gradients but which are not sufficient to cause the release of cytoplasmic contents . Some of these possible mechanisms will be discussed in more detail below. Amphipathic and hydrophobic . However, there are also . Peptides which are not cationic exhibit less selectivity towards microbes compared with mammalian cells. An example of a well- studied hydrophobic and negatively charged cytotoxic peptide is alamethicin. This helical peptide forms clusters of helices that traverse the bilayer and surround an aqueous pore which can transport ions . Another peptide that is hydrophobic and forms a helical transmembrane structure is gramicidin A. In membranes, it forms a cation- selective right- handed helix that traverses the membrane as a single- stranded head- to- head dimer . Both alamethicin and gramicidin are synthesized by microorganisms by a mechanism that does not involve ribosome synthesis. Since these peptides exhibit little selectivity for microbial membranes, their usefulness as specific pharmacological agents is limited. The majority of the cytotoxic amphipathic helical peptides are cationic and they do exhibit selective toxicity for microbes. One of the most studied of the cationic, antimicrobial, amphipathic helical peptides is magainin. This 2. 3 amino acid peptide is secreted on the skin of the African clawed frog, Xenopus laevis. The properties of this peptide have recently been reviewed . From these studies, the concept of a lytic pore has developed. This pore differs in a number of respects from the type of pore formed by helical clusters of peptides, such as that of alamethicin. In the case of magainin, the pore is larger and it does not have discrete open and closed states as conducting pores do. At the same time, the formation of this kind of pore does not result in complete lysis of the membrane. For example, magainin does not allow for the passage of trypsin, a protein of 2. Da . In addition, unlike the alamethicin pore which is lined with only peptide, the wall of the pore formed with magainin contains both lipid and peptide. Evidence for this comes from the fact that magainin stimulates the transbilayer movement of both peptide and lipid. The promotion of positive membrane bilayer curvature would be expected to facilitate the formation of a peptide- and lipid- lined pore and this is what has been found with magainin . However, it has also been observed that the model peptide 1. L, which has a consensus sequence for lytic peptides, promotes negative curvature, as does the wasp venom peptide mastoparan . The cyclic peptide, gramicidin S, promotes the formation of structures which give rise to isotropic 3. P NMR spectra, which may include the formation of inverted cubic phases . At least for zwitterionic membranes, leakage caused by peptides that promote negative curvature is more rapid with bilayers having a negative curvature strain . Current models of the large membrane pores formed by some antimicrobial peptides propose that the pore is lined with both peptide and lipid. The phospholipid in these pores would have a positive curvature and therefore, peptides that facilitated formation of structures with this curvature would facilitate pore formation. However, the mechanism by which peptides promoting negative curvature induce leakage is less well established. It could simply be explained by the pore which is formed being of a small diameter. The dependence of the curvature of a toroidal pore on its diameter is a consequence of the fact that there are two curvatures to consider. One is along the bilayer normal, which predominates in large pores, and the other is in the plane of the bilayer, which is of opposite sign and which predominates in small pores. The importance of the amphipathic helical conformation (Fig. D- isomers resulted in loss of helicity and of antimicrobial activity . However, the importance of an amphipathic helical conformation to the cytotoxic action of peptides was questioned in similar studies with the peptide pardaxin. Pardaxin is an amphipathic helical peptide that shows lytic activity with both microbial and mammalian cells. Incorporation of some D- amino acid residues into pardaxin converts the peptide conformation from an . The modified pardaxin with . Thus, the conformational property of an amphipathic.
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Get local Philadelphia news plus Philadelphia breaking news, business, green, national, and world news from NBC10 Philadelphia. The most vulnerable victims of America. At her sentencing, she said she had been . In an affidavit, the officer who went to Schlier. Build a powerful, secure ecommerce storefront with our Online Store Software. Sell, promote, and grow with the 1ShoppingCart.com Online Store Builder. Pearland PD: Jogger wearing headphones dies after being struck by boat trailer. Program To Help Single Mothers Get A CarThat effort is failing across the nation, a Reuters investigation has found, endangering a generation of children born into America. He trembled and wailed inconsolably, clenching his muscles and sometimes gasping for breath as he went through withdrawal. When Brayden improved, Lehigh Valley Hospital released him to Schlier and the boy. But doctors neglected to take a critical step: They failed to alert child protection workers to the baby or his drug- addicted mother. Three weeks later, Brayden was dead. Being born drug- dependent didn. Each recovered enough to be discharged from the hospital. What sealed their fates was being sent home to families ill- equipped to care for them. Like Brayden, more than 4. Thirteen died after swallowing toxic doses of methadone, heroin, oxycodone or other opioids. In one case, a baby in Oklahoma died after her mother, high on methamphetamine and opioids, put the 1. That number has grown dramatically in the years since. Using hospital discharge records, Reuters tallied more than 2. On average, one baby was born dependent on opioids every 1. The federal law calls on states to protect each of these babies, regardless of whether the drugs their mothers took were illicit or prescribed. Health care providers aren. They are supposed to alert child protection authorities so that social workers can ensure the newborn. But most states are ignoring the federal provisions, leaving thousands of newborns at risk every year. Reuters found that at least 3. No more than nine states and the District of Columbia appear to conform with the federal law. And statutes or policies in the other five states are murky and confusing, even for doctors and child protection workers. Interactive: How the children died. Policies deter doctors from reporting cases. U. S. In 7. 5 of the cases, child protection workers were notified but didn. Representative Jim Greenwood, a Republican from Pennsylvania who authored the provisions in the 2. That exemption stems from a well- meaning effort to avoid stigmatizing mothers who are being treated for addiction or other medical problems. Taking methadone under a doctor. In at least 3. 9 of the cases in which children died, Reuters found, the mother was taking methadone or another drug that had been prescribed. In each of the 2. Neonatal Abstinence Syndrome diagnosed in 2. Patient discharge records show they treated the child for the syndrome. Doctors who specialize in these cases say the condition, while sometimes agonizing for the newborn, is treatable and needn. But a diagnosis made in the first days of the baby. It often indicates that a mother is struggling with addiction, raising questions about a family. Reuters made that determination by comparing the number of newborns diagnosed by hospitals as drug- dependent with the number of cases referred to state child welfare authorities. Only seven states specifically tracked referrals of newborns in drug withdrawal. In those states, the total number of cases logged by child protection services was less than half the number of children diagnosed. Reuters filed more than 2. Freedom of Information Act requests with federal, state, county and city agencies, and reviewed about 5,8. United States to identify such cases. Reporters also scrutinized tens of thousands of pages of reports by police, hospitals, medics, coroners and lawyers. By examining fatality reports and other public records, the news agency was able to identify 1. The toll is almost certainly higher. Most states made available only partial information on the circumstances of infant deaths. Some of the largest states, including New York, declined to disclose any reports about child fatalities. Even so, researchers said the Reuters investigation represents the most comprehensive examination of the perils facing drug- dependent newborns after they are sent home. She called the Reuters findings . Less examined was whether babies born with narcotics in their bodies were in danger after they were treated and released from the. The amendment orders states to set up systems to ensure that each case in which a baby is born drug- dependent is reported to child protection authorities. Social services are then to develop a . At the time, the National Conference of State Legislatures said that many states would need to pass new laws to meet the federal provisions. Few have. Congress offers federal funding for states that comply with the law. But the amount of money tied to the provisions is. This year, it ranged from $8. District of Columbia, which does comply, to $2. California, which. Despite the widespread lack of compliance, Reuters found that no state has ever lost federal funding for failing to meet the law. That means child protection services may never learn of babies suffering withdrawal from opioids that were legally prescribed to pregnant mothers. Some state policies are so muddled that even child welfare officials are confused about the reporting requirements. Laura Velez, deputy commissioner of New York state. Those provisions run counter to the spirit of the federal law, which explicitly states that identifying a drug- dependent newborn shouldn. Some well- intentioned doctors say the punitive measures give hospitals a strong incentive to keep quiet about certain kinds of cases. In an October speech, President Obama said he . Last month, Congress passed a bill directing the administration to move faster and devise a national strategy within a year. A White House spokesman said the new law . Statistics showing the spike in cases have been available since at least 2. When are they going to start doing something? If you do not create the proper conditions for mother and child, when they go home it. As they go through withdrawal, some shake, struggle to eat and often sputter and choke during feedings. They suffer fits of sneezing and severe diarrhea. Many begin crying at the smallest stimulus, including a mother. They can cry with such force that their bodies shudder. The symptoms are often worst during the first five weeks of life but can last three to six months, challenging even the most patient parents. The newborns rarely achieve deep sleep. As they endure withdrawal, they crave the darkness and calm of the womb, conditions almost impossible to replicate at home. In West Virginia, cases have become so frequent that one hospital created a unit where babies are weaned off the drugs in dimly lit rooms, sheltered from bright light and commotion. The snapshot was taken the day before Mc. Kenney, high on a trio of drugs, fell asleep on top of Lynndaya and suffocated her. Child protection authorities weren. Under Kentucky law, the case didn. Five days later, on Dec. A 3. 6- page state report details the final hours of the newborn. The night before Lynndaya died, Mc. Kenney later told police, she took three different medications: the opioid Percocet, the anti- anxiety medication Xanax, and Subutex. Twice, the grandmother asked where the baby was. Then she saw a corner of Lynndaya. Local prosecutor Douglas Miller said there wasn. Harrison Memorial Hospital and the doctor who delivered Lynndaya knew of Mc. Kenney. The state report said that Lynndaya . But no report about Mc. Kenney. Hospital spokeswoman Mollie Smith declined to talk about the case, citing medical privacy. Derek Clarke, the doctor listed on the hospital discharge document, delivered Lynndaya by Cesarean section. He later sent Mc. Kenney home with the prescription for Percocet, one of the drugs she took the night before she smothered her baby. The discharge also notes that Mc. Kenney . The day before Lynndaya died, pharmacy records show, Clarke also prescribed Xanax, which Mc. Kenney took with the Percocet and Subutex. Studies have shown that combining Subutex and Xanax can be particularly dangerous. Clarke did not respond to questions about the Xanax prescription. Mc. Kenney said Clarke should have known better than to give her the prescriptions. It was my fault, of course, and also it was his fault for offering me the medicine. She said she wishes social services had been more involved when Lynndaya was born. In Utah, a 1. 7- month- old girl named Jaslynn Raquel Mansfield died last year of acute methadone toxicity. Her mother, Courtney Nicole Howell, was on prescription methadone during and after her pregnancy. The child died, and Howell was sentenced to up to 3. She says she wishes she had gotten help from social services. Her reasoning: Jaslynn . But the Salt Lake Regional Medical Center never reported the case to child protection services. Utah is among the states that don. Louise Swensen, director of risk management for the hospital, said a baby in withdrawal wouldn. Charri Brummer, deputy director of the state Division of Child and Family Services, said the state . In this case, she said, the state received no drug- related reports on Howell before Jaslynn. In many ways, Howell represented the kind of vulnerable parent the federal law was meant to help. Not only was her newborn going through withdrawal, but Howell also was homeless. After she and Jaslynn were released, Howell said, they went to live with her late boyfriend. She said the hospital gave her about four micro- doses of morphine to finish weaning Jaslynn off opioids. Howell herself continued to use methadone and other drugs, she said. Today, she said, she wishes she had been reported to child protection services when Jaslynn was born. In September, Brayden. At sentencing, she told a judge that she had been happy when she got pregnant but . When Tory was a teenager, her parents had sought the county. On probation for theft and pregnant with Brayden, Schlier was jailed in May 2. 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Kolej Universiti Islam Antarabangsa Selangor (Inggeris: Selangor International Islamic University College; pernah dikenali sebagai: Kolej Islam Selangor Darul Ehsan (KISDAR)) telah ditubuhkan pada 1. Majlis Agama Islam Selangor (MAIS) yang ditubuhkan di bawah Akta IPTS 1. Penubuhannya secara rasmi pada 1. Februari, 1. 99. 5 juga membuktikan komitmen kerajaan negeri dalam membangunkan agenda pendidikan dan kecemerlangan ilmu. Lokasi baru ini terletak kira- kira 2. Permohonan Program Ijazah Sarjana Muda Perguruan Lepasan SPM Ambilan Jun 2013. Permohonan kemasukan ke Program Ijazah Sarjana Muda Perguruan dengan Kepujian (PISMP) ambilan khas bagi lulusan Unified Examination Certificate (UEC) dan Sijil. Permohonan PISMP 2016 Program Ijazah Sarjana Muda Perguruan. Mungkin ada yang mengetahui apa itu pengajian di peringkat sijil, peringkat ijazah, sarjana dan PHD. Namun demikian masih ada yang bertanya dan minta penjelasan lebih. Saya berminat untuk menjawat jawatan pensyarah sambilan di uum untuk subjek sains. Kolej Universiti Islam Antarabangsa Selangor Bandaraya Kuala Lumpur dan 2. Lapangan Terbang Antarabangsa Kuala Lumpur di Sepang. Kampus ini secara rasminya dibuka oleh Sultan Sharafuddin Idris Shah Al- Haj, Sultan Selangor Darul Ehsan yang ke- 9 pada 2. Mei. 20. 02. Aspirasi dan komitmen KUIS ialah supaya menjadi institusi bertaraf dunia dan memimpin dalam pendidikan Islam swasta di Malaysia. Sejak penubuhannya, KUIS mengalami pertumbuhan populasi pelajar daripada hanya memiliki 6. ASEAN, Timur Tengah dan benua Afrika hinggalah ke China. Sehingga kini, KUIS telah menghasilkan lebih dari 3,0. Moto. Pemangkin Tradisi Ilmu. Visi. Memartabatkan KUIS sebagai sebuah Institusi Pengajian Tinggi Islam bertaraf dunia yang mendapat keredhaan Allah. Misi. Bertekad ke arah mencapai kecemerlangan pengurusan, akademik dan sahsiah pelajar melalui penggunaan teknologi terkini dan perkhidmatan berkualiti berteraskan Al- Quran dan Al- Sunnah. Falsafah. Kesepaduan antara ilmu, iman dan amal menjadi dasar ke arah melahirkan insan yang bertaqwa dan berketerampilan untuk menyumbang kepada kesejahteraan diri, masyarakat dan negara. Matlamat. Membentuk dan mendidik generasi ummah agar menjadi insan soleh melalui dasar pendidikan yang berteraskan ilmu naqli (revealed knowledge) dan ilmu aqli (acquired knowledge) yang berpaksikan tauhid untuk melahirkan generasi profesional yang seimbang bagi menghadapi cabaran zaman. Pengerusi : YAB Dato' Seri Mohamed Azmin Ali (Menteri Besar Selangor)Ahli Lembaga : - YB Dato' Haji Mohammed Khusrin Haji Munawi (Setiausaha Kerajaan Negeri Selangor)- YB Dato' Noordin Sulaiman (Pegawai Kewangan Negeri Selangor)- YB Tuan Mohd Azari Harun (Penasihat Undang- undang Negeri Selangor)- YBhg Dato' Setia Haji Mohamad Adzib Mohd Isa (Pengerusi Majlis Agama Islam Selangor)- YB Dato' Dr Ahmad Yunus Hairi (EXCO Agama Islam Negeri Selangor)- YBhg Sahibul Fadilah Dato' Haris Kassim (Pengarah Jabatan Agama Islam Selangor)- YBhg Prof. Dr Mujaini Tarimin (Dekan Fakulti Pendidikan dan Sains Sosial UNISEL)- YBhg Prof. Madya Dato' Dr Ab Halim Tamuri (Ketua Eksekutif / Rektor)Rektor : Prof. Halim Tamuri. Timbalan Rektor Akademik & Penyelidikan : Dr Mohamad Syukri Abdul Rahman. Timbalan Rektor Pembangunan Mahasiswa & Alumni : Dr Mokmin Basri. Timbalan Rektor Pengurusan Korporat Pembangunan & Pengantarabangsaan : Dr Zulkifli Abd Hamid. Pendaftar : En. Zulhizzam Hamzah. Bendahari : Pn. Nor Hafizin Abdul Wahab. Penasihat Undang- Undang : Pn. Rohaiza Mat Noh. Ketua Pustakawan : Cik Hajah Noorlia Ramli. Bersandarkan misi dan visi yang jelas, KUIS terus mengorak langkah ke hadapan mendepani pelbagai cabaran dan perubahan. Falsafah kesepaduan ilmu yang didukung adalah sejajar dengan hasrat kerajaan untuk membangunkan modal insan yang boleh memajukan negara di masa hadapan. Selaras dengan itu, KUIS telah menawarkan program pengajian ke 5 peringkat. Akademi Islam bertekad untuk melahirkan graduan yang kompeten bukan sahaja daripada aspek keilmuan tetapi juga akhlak dan kemahiran bagi mencapai matlamat mardhatillah. Bermula dengan Sekolah Pengajian Islam (SPI), kini Akademi Islam telah melahirkan ramai graduan dan cendekiawan yang tidak kurang hebatnya di peringkat domestik dan antarabangsa bagi meneruskan bidang industri pendidikan di Malaysia khususnya di Selangor. Pada masa kini Akademi Islam menawarkan 7 program diploma, 7 program Sarjana Muda dan 1 program Sarjana. Pendekatan yang dilakukan masih meneruskan kursus integrasi ilmu antara ilmu- ilmu asas Pengajian Islam dan bidang- bidang profesional seperti Multimedia, Komunikasi dan Pengurusan Sumber Insan. Mempunyai 8 buah jabatan, iaitu Jabatan Bahasa & Kesusasteraan Arab, Jabatan Syariah, Jabatan Usuluddin, Jabatan Al- Quran & Al- Sunnah, Jabatan Dakwah & Pengurusan, Jabatan Tahfiz Al- Quran & Al- Qiraat, Jabatan Undang- Undang dan Jabatan Bahasa Arab. Sarjana Syariah (Pengurusan) (Kepujian)Sarjana Muda Syariah dengan Undang- undang (Kepujian)Sarjana Muda Al- Quran dan Al- Sunnah dengan Komunikasi (Kepujian)Sarjana Muda Usuluddin Dengan Multimedia (Kepujian)Sarjana Muda Al- Quran Dan Al- Qiraat (Kepujian)Sarjana Muda Dakwah Dengan Pengurusan Sumber Insan (Kepujian)Sarjana Muda Bahasa Arab Sebagai Bahasa Kedua (Kepujian)Sarjana Muda Bahasa Arab (Terjemahan) (kepujian)Diploma Pengajian Islam (Syariah)Diploma Pengajian Islam (Usuluddin)Diploma Pengajian Islam (Al- Quran dan Al- Sunnah)Diploma Pengajian Islam (Dakwah)Diploma Tahfiz Al- Quran dan Al- Qiraat. Diploma Syariah & Perundangan Islam. Diploma Bahasa Arab. Fakulti Pengurusan dan Muamalah. Graduan fakulti ini diharapkan mampu memimpin masyarakat dalam pelbagai bidang pekerjaan berlandaskan prinsip dan ajaran Al- Quran. Kursus- kursus yang ditawarkan adalah bertujuan untuk meluaskan pengetahuan tentang Pengurusan Perniagaan mengikut perspektif Islam seperti Perbankan Islam, Insurans Islam, Etika Perniagaan Islam bersesuaian dengan dasar penerapan Islam yang diterapkan oleh kerajaan di kalangan kakitangan awam dan swasta. Pelajar akan didedahkan kepada prinsip- prinsip Islam yang berkaitan asas Pengurusan Perniagaan termasuk konsep Islam sebagai Ad- din, sumber- sumber hukum, asas muamalat, ekonomi Islam, riba, akad, zakat perniagaan, etika perniagaan Islam, prinsip- prinsip pengurusan dan kewangan Islam. Mempunyai 8 buah jabatan iaitu Jabatan Perakaunan, Jabatan Pengurusan Perniagaan, Jabatan Perbankan Dan Kewangan, Jabatan Pengurusan Potensi Insan, Jabatan Ekonomi, Jabatan Sains Kejururawatan, Jabatan Linguistik & Kesusasteraan Inggeris dan Jabatan Komunikasi. Sarjana Pentadbiran Perniagaan (Muamalah)Sarjana Muda Pentadbiran Perniagaan dengan E- Dagang (Kepujian)Sarjana Muda Pengurusan Sumber Insan (Kepujian)Sarjana Muda Ekonomi dan Kewangan (Kepujian)Sarjana Muda Perakaunan (Kepujian)Sarjana Muda Kewangan Islam (Perbankan) (Kepujian)Sarjana Muda Kewangan Islam (Pasaran Modal) (Kepujian)Sarjana Muda Kewangan Islam (Takaful) (Kepujian)Sarjana Muda Komunikasi (Penyiaran) (Kepujian)Diploma Perakaunan. Diploma Pengurusan Perniagaan. Diploma Perbankan Islam. Diploma Pengurusan Sumber Manusia. Diploma Ekonomi. Diploma Keusahawanan. Diploma Perancangan Kewangan Islam. Diploma Komunikasi. Diploma Pengajian Bahasa Inggeris. Diploma Kejururawatan. Fakulti Sains & Teknologi Maklumat. Kurikulum fakulti ini digubal dengan memberi penumpuan kepada teras dalam teknologi maklumat dan bidang sokongan yang membantu proses pembinaan kemahiran pelajar dalam hubungan kemanusiaan dan organisasi. Mempunyai 5 buah jabatan, iaitu Jabatan Teknologi Maklumat (Multimedia), Jabatan E- Dagang, Jabatan Sains Komputer, Jabatan Teknologi Rangkaian dan Jabatan Kemahiran & Kursus Teras. Sarjana Muda Teknologi Maklumat (Multimedia) (Kepujian)Sarjana Muda Teknologi Kejuruteraan Perisian Dengan Kepujian. Sarjana Muda Teknologi Maklumat (Teknologi Rangkaian) (Kepujian)Diploma Teknologi Maklumat (Multimedia)Diploma Sains Komputer. Diploma Teknologi E- Dagang. Fakulti Pendidikan. Ini juga selaras dengan misis fakulti iaitu melahirkan para pendidik yang berinovatif dan celik teknologi seiring dengan keperluan semasa, melahirkan para pendidik yang berupaya mengaplikasikan teori- teori pendidikan dalam pengajaran dan pembelajaran serta mengamalkan pembelajaran sepanjang hayat, dan melahirkan para pendidik yang dapat melaksanakan tugas berpandukan etika kerja yang cemerlang dan mampu berdaya saing. Mempunyai 4 buah jabatan, iaitu Jabatan Pendidikan Islam, Jabatan Pendidikan Bahasa, Jabatan Perkaedahan dan Jabatan Ko Kurikulum & Amalan Pendidikan. Diploma Perguruan ( Pengajaran Bahasa Arab Sebagai Bahasa Kedua) (TASL)Diploma Perguruan (Teaching English As A Second Language) (TESL)Diploma Perguruan (Pendidikan Islam)Pusat Asasi KUIS. Dengan kata lain, program- program yang ditawarkan di Pusat Asasi ini merupakan . Melalui program- program yang ditawarkan KUIS beriltizam untuk melahirkan pelajar- pelajar yang bakal menjadi pelajar cemerlang di peringkat ijazah pertama yang seterusnya menjadi graduan yang berkualiti, berketrampilan dan berdaya maju dalam bidang- bidang yang diceburi. Program- program di peringkat pra- ijazah yang ditawarkan merupakan . Ia memberi dan menambah peluang pengajian pra- universiti kepada Bumiputra Islam sebelum melangkah ke peringkat ijazah pertama. Di samping itu, ia adalah laluan singkat ke peringkat ijazah pertama di KUIS tanpa melalui program di peringkat diploma yang ditawarkan selama tiga tahun (atau enam semester). Justeru, pelajar lepasan SPM dari pelbagai jenis sekolah yang memperolehi pencapaian yang baik boleh dipertimbangkan untuk mengikuti program pengajian di peringkat asasi ini. Mempunyai 5 buah Jabatan, iaitu Jabatan Asasi Pengajian Islam, Jabatan Asasi Pengurusan, Jabatan Asasi Teknologi Maklumat, Jabatan Asasi Bahasa dan Jabatan Asasi Komunikasi. Kursus Asas Pengajian Islam. Pengajian Asasi Pengurusan. Pengajian Asas Teknologi Maklumat. Pengajian Tahun Asas Bahasa Arab. Pengajian Asas Komunikasi. Pusat Pengajian Siswazah (PPS). Senarai Bidang Penyelidikan Program . Kursus Syariah. - Fiqh, Usul dan Kaedah- Fiqh Mua'sarah- Syariah dan Ekonomi- Siyasah Syar'iyyah. Kursus Usuluddin. Al- Quran dan Hadis- Aqidah, Falsafah, Tasawwuf dan Pemikiran- Dakwah dan Pembangunan Insan- Perbandingan Agama. Kursus Pengajian Islam. Pendidikan Islam dan Teori Ilmu- Islam, Sains dan Teknologi- Islam dan Kajian Sosial- Sejarah dan Ketamaddunan Islam. Kursus Pengajian Perniagaan (berfokuskan perspektif Islam). Amazon.com Hot New Releases: The best-selling new & future releases in Children's Christmas Books. About Hot New Releases in Children's Christmas Books These lists, updated hourly, contain bestselling items. New Tool Previews, Best Tool Picks & Deals Blog. New Tools; Reviews; Guides. Sep 29, 2016 Stuart 34 Comments. The new Stanley FatMax adjustable wrench has a striking. Hottest Toys for Boys 2013: Top 10 Christmas Gifts. Published 1:39 pm EDT. These are the best presents for little bros. Hottest Toys for Girls 2013: Top 10 Christmas Gifts. Best Winter Trips 2013; All Best Trips. Best Winter Trips 2013. Best tech for men: T3's top gadget picks for any male; Best tech for men: T3's top gadget picks for any male. Here at T3 we thrive on covering the best gadgets and new tech. And, trust us when we say this. Woodworking Tools Home > Best Sellers > New Woodworking Tools. New Woodworking Tools for 2013. The 5 Best New Milwaukee Power Tools. Given the rapid development of its test and measurement tools, it was only a matter of time before Milwaukee hit the scene with this one. The tool senses temperature differences and displays them on a screen, letting you see the world as though you were the Predator. The Milwaukee imager has a temperature range of 1. Fahrenheit and a built- in camera. In the BBC Christmas 2013. Who could have guessed the Doctor's renewed regeneration cycle would be dealt with as simply as his best friend just. Tools/Machines New Products. New Woodworking Tools and New Woodworking Products. Monday, 12 September 2016 00:00 GRIZZLY INDUSTRIAL offers a pair of new heavy-duty wood lathes. Best of all, when you pull the trigger, the imager simultaneously takes two pictures- a thermal image and a regular image- so when it comes time to review the data, it's easy to see what you're looking at. Images are saved as JPEGs and can easily be downloaded to a computer. Woodworking Tools Home > Best Sellers > New Woodworking Tools >. New Woodworking Tools for 2013. Displaying products 1. According to Milwaukee, it's also durable enough to withstand a 6- foot drop. The thermal imager is costly, but it has the potential to save a homeowner a lot of money in the long run: One use of its thermal imaging could be to spot insulation gaps and other areas in a home where heat might escape. Best Men's Gifts: 1. Gifts for the do- it- yourselfer 2. Handyman, craftsman, mister- fix- it, Dad. Call him what you like, but the Do- It- Yourselfer on your list gives his all for you, no matter the task. Be honest: that beautiful new deck that causes envy in the eyes of all your friends would’ve been a creaking pile of splinters were it not for him, and you’d probably be sharing space with Fido out in the yard — in the K9 condo he designed and built no less — had he not stepped in to save your recent en suite experiment. Like most men of his ilk, your handyman rarely receives anything more than a hot coffee to start his day and a cold brew to finish it, which is fine by him. Isn’t it about time you gave him something more? Here are a few gift ideas that should ensure your calls for help continue to get answered. De. Walt 8. V Max Gyroscopic Screwdriver. We don’t like to admit it, but sometimes breaking out the big guns can be overkill — nobody needs a return trip to Ikea because an itchy trigger finger delaminated cabinet doors. To dial things back to “just right” while ensuring you need not stoop to manual labor levels, De. Walt created its 8. V Max Gyroscopic Screwdriver. Activated by the same directional motions of your wrist, the professional- grade cordless driver is our kind of twisted, intuitively delivering up to 2. He’ll never stop playing with it, trust us. Dropcam Pro Wi- Fi Wireless Video Monitoring Camera. Keeping an eye on the old homestead is becoming an increasingly easy task. Tethered to your home wi- fi network and viewable via your favorite i. OS device, the Dropcam Pro is the simplest security set- up yet. Mount the Dropcam where you need it most, boot up the accompanying i. OS app and within a few swipes and taps your new favorite channel is ready to watch. The Dropcam watches your stuff in 1. Just don’t forget to unplug once in a while. Nobody likes being called creepy. Craftsman Lighted Pliers. If you’ve never had to hold a flashlight between your teeth while working both ends of a bolt, on the side of the road, in the rain, you probably lease your vehicle may have just been saved that indignity. Craftsman has hopped on the LED bandwagon in the most useful way we’ve seen yet. Their new line of lighted pliers is nothing short of a toolbox essential. Each model — linesman, long- nose and diagonal — features an LED (completely sealed against oil and water) that rotates with the jaw- action to keep the work surface illuminated. Insert “bright idea” joke here. Robo. Reel Ceiling Mounted Power Cord System. If you haven’t yet fully subscribed to the cordless realm of electric power tools, wrapping up extension cords is still an all- too- annoying reality — but it doesn’t have to be. The Robo. Reel Ceiling Mounted Power Cord system features a motor- driven retractable 5. A full 3. 60- degree rotation and self- leveling mount means you can install the Robo. Reel anywhere without fear of entanglement. Cub Cadet RZT S- Zero Electric Zero- Turn Riding Mower. Weekends are precious. Having to wait for neighborly hours to tackle the lawn sucks. The Cub Cadet RZT S- Zero electric riding lawn mower is the world’s first all- electric, zero- turn, silent swathe cutter to hit the market, and we want one. Much like Cub Cadet’s other RZT mowers, the S- Zero offers unparalleled performance and ergonomics, minus the noise, oil, fuel, maintenance and heat of its gas- powered stablemates. A full charge is good for one hour of work, whenever you damn well please. Maker. Bot Digitizer. So, you followed our advice last year, but your handyman’s homemade model making has stagnated since? Fear not dear friend: the Maker. Bot Digitizer desktop 3. D scanner will have mister- fix- it back in a plastic- fantastic state of mind in no time. After just a couple of clicks on your part, the Digitizer takes a three- dimensional photo of any object rotating on its scanner bed and preps a watertight rendering that can be easily edited before heading to production. If you opted to look elsewhere for his 3. D printing fix it matters not: the Maker. Bot Digitizer plays just as well with others as it does with its own kind. Bradley 6- Rack Digital Smoker. Doing man’s work requires sustenance. A thick juicy steak on the grill may be de rigueur for most, but few foods start us salivating like those of the smoked variety. Spoil your do- it- yourselfer (and yourself in the process) by squeezing a Bradely 6- Rack Digital Smoker under the tree this year. The Bradley Digital eliminates the need to monitor the slow- cooking process by offering up to 8- hours of cool, controlled smoke. It even sports an automatic briquette conveyor that delivers a more constant source of smoke than a Snoop Dog concert in Tijuana. Philips Friends of Hue Lightstrips. Looking to add a little ambience to your newly minted kitchen? Did you think far enough ahead to pre- wire your cabinetry? How about behind your speakers? The Philips Friends of Hue line of malleable LEDs easily attaches to any solid surface to add accent lighting wherever you like. Like all Hue products, these LED lightstrips are controlled by your favorite i. OS device and feature an on- the- fly adjustability to shine any one of 1. Just don’t go too crazy — even Disco Stu doesn’t advertise. Dremel 4. 20. 0- 8/6. Platinum Edition. Rotary tools are a workshop essential, and Dremel makes the best, bar none. Their new 7. 7- pc Platinum Edition kit ups the ante by featuring the highest performing Dremel motor to date, now with better venting to allow for cool(er) runnings. Dremel’s patented EZ Drum, Lock and Change features are all present, as are 7. Chances are you’ll run out of work before you get to use every attachment, but it’s always nice to be prepared. Wall Control Galvanized Steel Pegboard. Your do- it- yourselfer has just about every hand tool known to man. He takes care of them like they’re his children and proudly displays the most exceptional of the bunch. The only problem is, they hang precariously from a wilting card stock pegboard he inherited from his dad that, sadly, is not worth the six- penny nails it’s secured with. The Wall Control Galvanized Steel Pegboard Tool Organizer offers up the requisite toughness for keeping his trophies on display while adding the right amount of bad- ass bling to make his workshop really shine. Pebble Smartwatch. On the job, most contractors are forced to forego fancy wrist wear for fear of scratches. Ditto smartphones, which need ballistic packaging to keep from cracking or getting zapped by stray water. Kill two birds with one pebble this Christmas by wrapping up a new Pebble Smartwatch. Built with a scratch- and shatter- resistant lens, the Pebble will do more than just remind him when it’s quitting time. Using Bluetooth technology, the Pebble links to his smartphone to deliver texts and emails at a glance while also offering up some remote controls. We like the high- vis orange colorway for obvious reasons. Now they’ve gone and added an industrial- duty refrigerator to their lineup. Finished in diamond- plate accented stainless steel and featuring the same locking castors found on most tool- boxes, the Chillerator is all business. Nineteen cubic feet of temperature- regulated storage will hold enough afterwork refreshment for the whole crew. Now if we could only find our bottle opener. Madonna - The Confessions Tour. Qpbh. DFM/Madonn. Madonna - The Confessions Tour. Qpbh. DFM/Madonna. 017 - hung up - madonna, 01 Hung Up (Madonna-Addiction 80's Mix Edit) hung up madonna. Madonna Vs Gorillaz I Feel Good Coz I'm Hung Up Saint Ken Mash rapidshare. Madonna Celebration Benny Benassi Mixes Promo CDS 2009 WUS. Servicio de Rescate. SH1. 09. 3chicas de secundaria ense. By Light GM) (Www. Sabor. Urbano. Com).
Qualcomm and Verizon Wireless' nPhase joint venture has introduced a new M2M developer program so that companies won't have to reinvent the wheel to create a new M2M device.View M2M Developer Platforms. Verizon Wireless 4G LTE Application Developer Guide. Site Map About Us Careers Corporate Responsibility HopeLine Verizon Innovation Program Radio Frequency Emissions Avoid Potential. The European M2M Partner Program offers you a carefully selected set of M2M solutions from Deutsche Telekom and their long-term partners. Global M2M Association & Bridge Alliance. The GMA is an association. Verizon M2. M Developer Program. ThingSpace Developer Community. If you've been thinking about integrating M2M device connectivity, monitoring, management, and control into your new or existing application, Verizon has the experience, programs, and assets. Gartner Positions Verizon in the Leaders Quadrant of the Magic Quadrant of Machine- to- Machine Services. BASKING RIDGE, N. J. This report marks Gartner's first- ever analysis of the global M2. M services landscape. Customizable solutions make today's business world more agile. From asset tracking and wireless backup to managed ATMs, conditioned- based monitoring, mobile health, mobile retail, energy management, car sharing, fleet management and other telematics capabilities, Verizon and its partners offer customizable solutions — leveraging the power of Verizon's intelligent networks, cloud and security platforms — to suit the specific needs of any industry or organization. Smart Cities are more secure and sustainable. Verizon has created a smart cities test bed at its Innovation Center in Waltham, Massachusetts, to showcase new innovative technologies, such as smart parking, traffic management, emergency response, smart street lighting and environmental solutions, including water and waste management, to address current and future needs of urban planners, CIOs and mayors. Connected cars help save lives. Verizon's global telematics solution offers a complete set of personalized and connected services that enhance safety, security and convenience — while boosting brand loyalty and creating new opportunities for ongoing revenue for automakers, insurance companies and their ecosystem partners. An expansive developer community drives innovation. Verizon's M2. M Developer Program offers a wealth of resources across multiple industries for developers through step- by- step guidelines in building their own M2. M solutions. Visit Verizon Enterprise Solutions to learn how machine- to- machine solutions can improve your business. Verizon Communications Inc. Verizon Wireless operates America's most reliable wireless network, with more than 1. Verizon also provides converged communications, information and entertainment services over America's most advanced fiber- optic network, and delivers integrated business solutions to customers in more than 1. A Dow 3. 0 company with more than $1. Verizon employs a diverse workforce of 1. For more information, visit www. Prospective students searching for Top Biomedical Engineering Graduate Programs: List of Schools found the articles, information, and resources on this page helpful. See the list of the top ranked online graduate engineering programs at US News.Top Financial Engineering Programs (Quant Network)Financial Engineering Overview: As the role of the so- called quant has grown in importance within Wall Street firms and the broader financial services industry, a new academic specialty has developed in its wake. Degrees in financial engineering, mathematical finance, financial mathematics, quantitative finance or computational finance. For the prospective quant, this presents an alternative to obtaining an MBA in addition to a degree in engineering, mathematics, physics or other highly quantitative fields. The 2. 01. 1 Quant. Net Ranking: The Quant Network. It boasts 1. 3,0. Quant. Net rated a preselected group of 2. North American master's degree programs in financial engineering (MFE) in July and August 2. Factors used to rank the programs were: Frequency with which employers interviewed or hired graduates. Starting salaries. Employment rate at graduation. Employment rate three months after graduation. Student to administrator ratio. Average GRE quantitative scores of students. Average undergraduate GPA of students. The percentage of applicants accepted. The latter three measures indicate the selectivity of the program. The more selective, the higher the program ranks. Top 10 Engineering schools in Canada - yconic community discussion. Join today to give and get help.
Caveats with the Quant. Net Ranking: The ranking started out with a preselected list of 2. Data from the schools were not independently audited. Surveys of employers went to a select list, of which only 3. The survey favors programs with fewer students per administrator, though the supposed benefit gained by the student from this cost- increasing factor is not described. Finally, as with any degree program. What you need at this point is a speech writing software which will help bridge the gap and meet your. However these speeches maybe impersonal or mechanical as they are written without you in mind therefore the need for.Free Sample of Speeches. Sample welcome speeches for church programs. Sample Welcome Speech For Church Program. Church Welcome and Occasion Speeches welcome speeches church programs.’s. Church choir anniversary of 48 years a sample welcome, You. Impress your audience by buying online an instant speech pack from professional speech writers. Our speeches will help you make it as perfect as you want it to. Thanks for visiting, Adam.help in writing speeches Speech writing by the pros - order a personalized speech for any occasion. Over 100 speeches by Barack Obama. Complete and full text of each speech. Writing persuasive speeches give good reasoning for your view.How to Write a Persuasive Speech 2. A Persuasive Writing Activity. 100% beneficial loyalty and referral programs; Regular bonuses and super sales. Writing speeches is a lucrative and interesting genre for freelance writers and career. Find free sample of speeches all in one place. A page for all the free speech samples offered at Best Speech Topics. Send in your own example speech and show off your talents! |
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